Neurobiology of Disease Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer’s Disease
نویسندگان
چکیده
Xibin Liang,1 Qian Wang,1 Tracey Hand,1 Liejun Wu,1 Richard M. Breyer,3 Thomas J. Montine,4 and Katrin Andreasson1,2 Departments of 1Neurology and 2Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, 3Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and 4Department of Pathology, University of Washington, Seattle, Washington 98104
منابع مشابه
Rosmarinic acid mitigates learning and memory disturbances in amyloid β(25–35)-induced model of Alzheimer’s disease in rat
Abstract Background and Objective: Alzheimer’s disease (AD) is a weakening neurodegenerative disorder typified by increased b-amyloid (Ab) deposition and neuronal dysfunction causing to impaired learning and memory. Among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. The aim of this study was to determine the effects of the rosmarinic acid on lear...
متن کاملA Search for Mitochondrial Damage in Alzheimer’s Disease Using Isolated Rat Brain Mitochondria
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (...
متن کاملVitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease
Objective(s): Vitamin E may have beneficial effects on oxidative stress and Aβ-associated reactive oxygen species production in Alzheimer’s disease. But, the exact role of vitamin E as a treatment for Alzheimer’s disease pathogenesis still needs to be studied. Hence, we examined the therapeutic effects of vitamin E on the density of congophilic amyloid plaques and neur...
متن کاملA Search for Mitochondrial Damage in Alzheimer’s Disease Using Isolated Rat Brain Mitochondria
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. The pathological initiation and progression of AD is highly complex and its prevalence is on the rise. In his study, Alzheimer's disease was induced with single injection of amyloid-β (Aβ) peptides (...
متن کاملInvolvement of TRPM7 calcium channels and PI3K/AKT kinase pathway in protective effect of vascular endothelial growth factor in amyloid beta-induced model of Alzheimer’s disease
Background and Objective: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, in which cortical and hippocampus neurons death is the main target of neurodegeneration. In addition to extracellular beta amyloid accumulation and the production of neural tangles, one of effective factors in the pathology of Alzheimer's disease is vascular injury in the elderly including disturbanc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005